Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer

Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer

The dysregulation of post-translational modifications (PTM) transversally impacts cancer hallmarks and constitutes an appealing vulnerability for drug development. In breast cancer there is growing preclinical evidence of the role of ubiquitin and ubiquitin-like SUMO and Nedd8 peptide conjugation to...

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Bibliographic Details
Main Authors: Jesús Fuentes-Antrás, Ana Lucía Alcaraz-Sanabria, Esther Cabañas Morafraile, María del Mar Noblejas-López, Eva María Galán-Moya, Mariona Baliu-Pique, Igor López-Cade, Vanesa García-Barberán, Pedro Pérez-Segura, Aránzazu Manzano, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
post-translational modification
ubiquitination
SUMOylation
neddylation
breast cancer
biomarkers
Online Access:https://www.mdpi.com/2072-6694/13/4/833

Internet

https://www.mdpi.com/2072-6694/13/4/833

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