<i>Panax notoginseng</i> Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

<i>Panax notoginseng</i> Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

Oxidative stress plays a critical role in cerebral ischemia/reperfusion (I/R)-induced blood-brain barrier (BBB) disruption. <i>Panax notoginseng</i> saponins (PNS) possess efficient antioxidant activity and have been used in the treatment of cerebral ischemic stroke in China. In this stu...

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Bibliographic Details
Main Authors: Shaonan Hu, Yali Wu, Bo Zhao, Haiyan Hu, Baochen Zhu, Zongxi Sun, Pengyue Li, Shouying Du
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
<i>Panax notoginseng</i> saponins
oxygen-glucose deprivation/reperfusion
anti-oxidative stress
blood-brain barrier
Online Access:https://www.mdpi.com/1420-3049/23/11/2781

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https://www.mdpi.com/1420-3049/23/11/2781

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