Shorter maintenance therapy in childhood Acute Lymphoblastic Leukemia. The experience of the prospective, randomized Brazilian GBTLI ALL-93 protocol.

Shorter maintenance therapy in childhood Acute Lymphoblastic Leukemia. The experience of the prospective, randomized Brazilian GBTLI ALL-93 protocol.

Maintenance therapy is an important phase of the childhood ALL treatment, requiring 2-year long therapy adherence of the patients and families. Weekly methotrexate (MTX) with daily 6-mercaptopurine (6MP) constitutes the backbone of maintenance therapy. Reduction in the maintenance therapy could over...

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Main Authors: Silvia Regina Brandalise, Marcos Borato Viana, Vitória Régia Pereira Pinheiro, Núbia Mendonça, Luiz Fernando Lopes, Waldir Veiga Pereira, Maria Lúcia de Martino Lee, Elitânia Marinho Pontes, Gláucia Perini Zouain-Figueiredo, Alita da Cunha Andrade Cirne Azevedo, Maria Zélia Fernandes, Nilma Pimentel, Hilda Maria Oliveira, Sônia Rossi Vianna, Fernando de Almeida Werneck, Carlos Alberto Scrideli, Maria Nunes Álvares, Érica Boldrini, Sandra Regina Loggetto, Paula Bruniera, Maria José Mastellaro, Eni Souza, Rogério Agenor Araújo, Flávia Bandeira, Doralice Marvulle Tan, Nelson Aquino de Carvalho, Maria Alessandra Silva Salgado
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Pediatrics
Subjects:
CHILDHOOD acute lymphoblastic leukemia
Maintenance ALL Chemotherapy
ALL Survival and childhood nutrition
Pediatric ALL Survival in Middle-Low-Income Countries
Race and ALL Survival in children
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2016.00110/full

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http://journal.frontiersin.org/Journal/10.3389/fped.2016.00110/full

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