MicroRNA-regulated transcriptome analysis identifies four major subtypes with prognostic and therapeutic implications in prostate cancer

MicroRNA-regulated transcriptome analysis identifies four major subtypes with prognostic and therapeutic implications in prostate cancer

MicroRNA (miRNA) deregulation plays a critical role in the heterogeneous development of prostate cancer (PCa) by tuning mRNA levels. Herein, we aimed to characterize the molecular features of PCa by clustering the miRNA-regulated transcriptome with non-negative matrix factorization. Using 478 PCa sa...

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Bibliographic Details
Main Authors: Bing-Biao Lin, Han-Qi Lei, Hai-Yun Xiong, Xing Fu, Fu Shi, Xiang-Wei Yang, Ya-Fei Yang, Guo-Long Liao, Yu-Peng Feng, Dong-Gen Jiang, Jun Pang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Prostate cancer
miRNAs
Molecular subtypes
Heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021003779

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http://www.sciencedirect.com/science/article/pii/S2001037021003779

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