Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

Pneumococcal whole cell vaccines (WCVs) could cost-effectively protect against a greater strain diversity than current capsule-based vaccines. Immunoglobulin G (IgG) responses to a WCV were characterised by applying longitudinally-sampled sera, available from 35 adult placebo-controlled phase I tria...

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Bibliographic Details
Main Authors: Joseph J Campo, Timothy Q Le, Jozelyn V Pablo, Christopher Hung, Andy A Teng, Hervé Tettelin, Andrea Tate, William P Hanage, Mark R Alderson, Xiaowu Liang, Richard Malley, Marc Lipsitch, Nicholas J Croucher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
S. pneumoniae
protein antigen
vaccine
antigenic diversity
panproteome array
antibody
Online Access:https://elifesciences.org/articles/37015

Internet

https://elifesciences.org/articles/37015

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