Premature Vascular Aging with Features of Plaque Vulnerability in an Atheroprone Mouse Model of Hutchinson–Gilford Progeria Syndrome with <i>Ldlr</i> Deficiency

Premature Vascular Aging with Features of Plaque Vulnerability in an Atheroprone Mouse Model of Hutchinson–Gilford Progeria Syndrome with <i>Ldlr</i> Deficiency

Hutchinson–Gilford progeria syndrome (HGPS) is among the most devastating of the laminopathies, rare genetic diseases caused by mutations in genes encoding nuclear lamina proteins. HGPS patients age prematurely and die in adolescence, typically of atherosclerosis-associated complications. The mechan...

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Bibliographic Details
Main Authors: Rosa M. Nevado, Magda R. Hamczyk, Pilar Gonzalo, María Jesús Andrés-Manzano, Vicente Andrés
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
aging
atherosclerosis
lamin A
progeria
vulnerable plaque
Online Access:https://www.mdpi.com/2073-4409/9/10/2252

Internet

https://www.mdpi.com/2073-4409/9/10/2252

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