Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases

Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases

Autoinflammatory diseases (AIDs) are heterogeneous disorders characterized by dysregulation in the inflammasome, a large intracellular multiprotein platform, leading to overproduction of interleukin-1(IL-1)β that plays a predominant pathogenic role in such diseases. Appropriate treatment is...

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Bibliographic Details
Main Authors: Alessandra Bettiol, Giuseppe Lopalco, Giacomo Emmi, Luca Cantarini, Maria Letizia Urban, Antonio Vitale, Nunzio Denora, Antonio Lopalco, Annalisa Cutrignelli, Angela Lopedota, Vincenzo Venerito, Marco Fornaro, Alfredo Vannacci, Donato Rigante, Rolando Cimaz, Florenzo Iannone
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
Interleukin-1
anakinra
canakinumab
innovative biotechnologies
autoinflammatory disease
Kawasaki disease
systemic juvenile idiopathic arthritis
personalized medicine
child
pediatrics
Online Access:https://www.mdpi.com/1422-0067/20/8/1898

Internet

https://www.mdpi.com/1422-0067/20/8/1898

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