Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Abstract Demyelinated lesions in human pons observed after osmotic shifts in serum have been referred to as central pontine myelinolysis (CPM). Astrocytic damage, which is prominent in neuroinflammatory diseases like neuromyelitis optica (NMO) and multiple sclerosis (MS), is considered the primary e...

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Bibliographic Details
Main Authors: Melanie Lohrberg, Anne Winkler, Jonas Franz, Franziska van der Meer, Torben Ruhwedel, Nikoloz Sirmpilatze, Rakshit Dadarwal, Ronja Handwerker, Daniel Esser, Kerstin Wiegand, Christian Hagel, Andreas Gocht, Fatima Barbara König, Susann Boretius, Wiebke Möbius, Christine Stadelmann, Alonso Barrantes-Freer
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Acta Neuropathologica Communications
Subjects:
Remyelination
Oligodendrocyte precursor cells
Neural stem cells
Multiple sclerosis
Astrocytes
Online Access:https://doi.org/10.1186/s40478-020-01105-2

Internet

https://doi.org/10.1186/s40478-020-01105-2

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