Long-term alterations of cytokines and growth factors expression in irradiated tissues and relation with histological severity scoring.

PURPOSE: Beside its efficacy in cancer treatment, radiotherapy induces degeneration of healthy tissues within the irradiated area. The aim of this study was to analyze the variations of proinflammatory (IL-1α, IL-2, IL-6, TNF-α, IFN-γ), profibrotic (TGF-β1), proangiogneic (VEGF) and stem cell mobili...

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Bibliographic Details
Main Authors: Patrice Gallet, Bérengère Phulpin, Jean-Louis Merlin, Agnès Leroux, Pierre Bravetti, Hinda Mecellem, Nguyen Tran, Gilles Dolivet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3245280?pdf=render