Continuous melt granulation to develop high drug loaded sustained release tablet of Metformin HCl

Continuous melt granulation to develop high drug loaded sustained release tablet of Metformin HCl

The present work explores the application of melt granulation technology to develop a high drug loaded sustained release matrix tablet of Metformin HCl using hydroxypropylcellulose (HPC) as a hydrophilic binder and stearic acid as an extrusion aid for producing cohesive granules. This novel approach...

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Bibliographic Details
Main Authors: Pradnya Vaingankar, Purnima Amin
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Metformin hydrochloride
Hydroxypropylcellulose
High drug loaded tablet
Melt granulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300769

Internet

http://www.sciencedirect.com/science/article/pii/S1818087616300769

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