Upgrading ketone synthesis direct from carboxylic acids and organohalides

Due to their abundance and importance in organic chemistry, development of methods for ketone synthesis is essential. Here, the authors report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of aromatic acids and aryl/alkyl bromides to directly synthesise ketone...

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Main Authors:	Rehanguli Ruzi, Kai Liu, Chengjian Zhu, Jin Xie
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17224-2

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record_format	Article
spelling	doaj-918a6d6aace14057b1822f8b673afe1c2021-07-04T11:47:41ZengNature Publishing GroupNature Communications2041-17232020-07-011111910.1038/s41467-020-17224-2Upgrading ketone synthesis direct from carboxylic acids and organohalidesRehanguli Ruzi0Kai Liu1Chengjian Zhu2Jin Xie3State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityDue to their abundance and importance in organic chemistry, development of methods for ketone synthesis is essential. Here, the authors report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of aromatic acids and aryl/alkyl bromides to directly synthesise ketones.https://doi.org/10.1038/s41467-020-17224-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rehanguli Ruzi Kai Liu Chengjian Zhu Jin Xie
spellingShingle	Rehanguli Ruzi Kai Liu Chengjian Zhu Jin Xie Upgrading ketone synthesis direct from carboxylic acids and organohalides Nature Communications
author_facet	Rehanguli Ruzi Kai Liu Chengjian Zhu Jin Xie
author_sort	Rehanguli Ruzi
title	Upgrading ketone synthesis direct from carboxylic acids and organohalides
title_short	Upgrading ketone synthesis direct from carboxylic acids and organohalides
title_full	Upgrading ketone synthesis direct from carboxylic acids and organohalides
title_fullStr	Upgrading ketone synthesis direct from carboxylic acids and organohalides
title_full_unstemmed	Upgrading ketone synthesis direct from carboxylic acids and organohalides
title_sort	upgrading ketone synthesis direct from carboxylic acids and organohalides
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Due to their abundance and importance in organic chemistry, development of methods for ketone synthesis is essential. Here, the authors report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of aromatic acids and aryl/alkyl bromides to directly synthesise ketones.
url	https://doi.org/10.1038/s41467-020-17224-2
work_keys_str_mv	AT rehanguliruzi upgradingketonesynthesisdirectfromcarboxylicacidsandorganohalides AT kailiu upgradingketonesynthesisdirectfromcarboxylicacidsandorganohalides AT chengjianzhu upgradingketonesynthesisdirectfromcarboxylicacidsandorganohalides AT jinxie upgradingketonesynthesisdirectfromcarboxylicacidsandorganohalides
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Upgrading ketone synthesis direct from carboxylic acids and organohalides

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