Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells.

Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells.

Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are used to reduce cholesterol biosynthesis in the liver. Accordingly, statins regulate nitric oxide (NO) and glutamate metabolism, inflammation, angiogenesis, immunity and endothelial progenitor cells (EPCs) functions...

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Main Authors: Kuang-Hsing Chiang, Wan-Li Cheng, Chun-Ming Shih, Yi-Wen Lin, Nai-Wen Tsao, Yung-Ta Kao, Chih-Ting Lin, Shinn-Chih Wu, Chun-Yao Huang, Feng-Yen Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4550447?pdf=render

Internet

http://europepmc.org/articles/PMC4550447?pdf=render

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