Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations

Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations

Abstract Background The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. Methods Peripheral blood mononuclear cells from healthy donors were incubated with different JAKis, levels of...

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Bibliographic Details
Main Authors: Iain B. McInnes, Nicole L. Byers, Richard E. Higgs, Jonathan Lee, William L. Macias, Songqing Na, Robert A. Ortmann, Guilherme Rocha, Terence P. Rooney, Thomas Wehrman, Xin Zhang, Steven H. Zuckerman, Peter C. Taylor
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Arthritis Research & Therapy
Subjects:
Baricitinib
Cytokine
Janus kinase
Phosphorylated signal transducer and activator of transcription
Potency
Receptor kinase signaling
Online Access:http://link.springer.com/article/10.1186/s13075-019-1964-1

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http://link.springer.com/article/10.1186/s13075-019-1964-1

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