Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation

Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation

Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability leading to frequent over- and under-immunosuppression. While routine therapeutic drug monitoring (T...

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Bibliographic Details
Main Authors: Pere Fontova, Helena Colom, Raül Rigo-Bonnin, Lisanne N. van Merendonk, Anna Vidal-Alabró, Nuria Montero, Edoardo Melilli, Maria Meneghini, Anna Manonelles, Josep M. Cruzado, Juan Torras, Josep Maria Grinyó, Oriol Bestard, Nuria Lloberas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
pharmacodynamic
pharmacokinetics
circadian rhythm
kidney transplantation
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.636048/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.636048/full

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