The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the microprocessor complex required for miRNA synthesis. Comp...

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Bibliographic Details
Main Authors: Tsui Han Loo, Xiaoqian Ye, Ruth Jinfen Chai, Mitsuteru Ito, Gisèle Bonne, Anne C Ferguson-Smith, Colin L Stewart
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
LINC complex
Sun1
Drosha
RTL1
muscle fiber
regeneration
Online Access:https://elifesciences.org/articles/49485

Internet

https://elifesciences.org/articles/49485

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