A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of <i>Plasmodium vivax</i> Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic <i>Plasmodium berghei</i> Parasite

A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of <i>Plasmodium vivax</i> Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic <i>Plasmodium berghei</i> Parasite

Infections with <i>Plasmodium vivax</i> are predominant in the Americas, representing 75% of malaria cases. Previously perceived as benign, malaria vivax is, in fact, a highly debilitating and economically important disease. Considering the high complexity of the malaria parasite life cy...

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Bibliographic Details
Main Authors: Luciana C. Lima, Rodolfo F. Marques, Alba Marina Gimenez, Katia S. Françoso, Eduardo Aliprandini, Tarsila M. Camargo, Anna Caroline C. Aguiar, Dhelio B. Pereira, Laurent Renia, Rogerio Amino, Irene S. Soares
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Microorganisms
Subjects:
malaria vaccine
<i>Plasmodium vivax</i>
circumsporozoite protein
apical membrane antigen 1
Online Access:https://www.mdpi.com/2076-2607/8/6/916

Internet

https://www.mdpi.com/2076-2607/8/6/916

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