Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targe...

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Bibliographic Details
Main Authors: Jeong Shim, MD, Christian Bo Poulsen, MD, PhD, Mette K. Hagensen, MSc, PhD, Torben Larsen, MSc, PhD, Peter M.H. Heegaard, MSc, PhD, Christina Christoffersen, MD, PhD, DMSc, Lars Bolund, MD, DMSc, Mette Schmidt, DVM, PhD, Ying Liu, MSc, PhD, Juan Li, MSc, PhD, Rong Li, MSc, PhD, Henrik Callesen, DVM, PhD, DrVetSci, Jacob F. Bentzon, MD, PhD, Charlotte B. Sørensen, MSc, PhD
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:JACC: Basic to Translational Science
Subjects:
apolipoprotein E
atherosclerosis
pig
remnant cholesterol dysbetalipoproteinemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17301444

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http://www.sciencedirect.com/science/article/pii/S2452302X17301444

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