Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line

Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line

Chlorpromazine (CPZ) is a neuroleptic drug and prototype compound used to study intrahepatic cholestasis. The exact mechanisms of CPZ induced cholestasis remain unclear. Rat hepatocytes, or a sandwich culture of rat and human hepatocytes, have been the most commonly used models for studying CPZ toxi...

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Bibliographic Details
Main Authors: Katie Morgan, Nicole Martucci, Ada Kozlowska, Wesam Gamal, Filip Brzeszczyński, Philipp Treskes, Kay Samuel, Peter Hayes, Lenny Nelson, Pierre Bagnaninchi, Joanna Brzeszczynska, John Plevris
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chlorpromazine
HepaRG
Cell membrane
Tight junctions
ECIS
Pro-inflammatory
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218372676

Internet

http://www.sciencedirect.com/science/article/pii/S0753332218372676

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