Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Abstract Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis is considered to be a novel anti-cancer strategy. T...

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Bibliographic Details
Main Authors: Jingjing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen, Xun Zhang, Noor Ul Hassan Khan, Linbo Wang, Jichun Zhou
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Metformin
Ferroptosis
UFMylation
SLC7A11
Breast cancer
Online Access:https://doi.org/10.1186/s13046-021-02012-7

Internet

https://doi.org/10.1186/s13046-021-02012-7

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