The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells

The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells

The microtubule (MT)-associated protein Tau is a natively unfolded protein, involved in a number of neurodegenerative disorders, collectively called tauopathies, aggregating in neurofibrillary tangles (NFT). It is an open question how the conversion from a MT bound molecule to an aggregation-prone T...

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Bibliographic Details
Main Authors: Cristina Di Primio, Valentina Quercioli, Giacomo Siano, Matteo Rovere, Branislav Kovacech, Michal Novak, Antonino Cattaneo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Tau
biosensor
conformation
FRET
FRAP
mutation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00210/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00210/full

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