Insulinotropic and anti-apoptotic effects of nobiletin in INS-1D β-cells

Insulinotropic and anti-apoptotic effects of nobiletin in INS-1D β-cells

To determine the mechanism underlying anti-diabetic effects of nobiletin, a citrus flavonoid, the effects of nobiletin on insulin secretion and β-cell apoptosis were investigated in the INS-1D β-cell line. Nobiletin increased glucose-induced insulin secretion (GSIS), and inhibited thapsigargin-induc...

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Bibliographic Details
Main Authors: Miki Takii, Yukiko K. Kaneko, Kiriko Akiyama, Yuki Aoyagi, Yuki Tara, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan, Kiyomitsu Nemoto, Tomohisa Ishikawa
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Journal of Functional Foods
Subjects:
Nobiletin
Pancreatic β-cells
Insulin secretion
β-Cell apoptosis
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616304364

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http://www.sciencedirect.com/science/article/pii/S1756464616304364

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