Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.

The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson's disease at 1-, 2-, 4-, 8-, 12-, and 16-months of age. The evaluation consisted of histopathology and ultrastructure examination of selected organs, including the kidneys, lungs,...

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Bibliographic Details
Main Authors: Marco A S Baptista, Kuldip D Dave, Mark A Frasier, Todd B Sherer, Melanie Greeley, Melissa J Beck, Julie S Varsho, George A Parker, Cindy Moore, Madeline J Churchill, Charles K Meshul, Brian K Fiske
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3828242?pdf=render

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http://europepmc.org/articles/PMC3828242?pdf=render

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