Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells

Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells

We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-induced responses were characterized by high levels...

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Bibliographic Details
Main Authors: Robert C. Kauffman, Taufiqur R. Bhuiyan, Rie Nakajima, Leslie M. Mayo-Smith, Rasheduzzaman Rashu, Mohammad Rubel Hoq, Fahima Chowdhury, Ashraful Islam Khan, Atiqur Rahman, Siddhartha K. Bhaumik, Levelle Harris, Justin T. O'Neal, Jessica F. Trost, Nur Haq Alam, Algis Jasinskas, Emmanuel Dotsey, Meagan Kelly, Richelle C. Charles, Peng Xu, Pavol Kovááč, Stephen B. Calderwood, Edward T. Ryan, Phillip L. Felgner, Firdausi Qadri, Jens Wrammert, Jason B. Harris
Format: Article
Language:English
Published: American Society for Microbiology 2016-12-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/6/e02021-16

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http://mbio.asm.org/cgi/content/full/7/6/e02021-16

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