Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge.

Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge.

Intramuscular (IM) vaccination with formalin-inactivated respiratory syncytial virus (FI-RSV) failed in clinical trials due to vaccine-enhanced respiratory disease. To test the efficacy of skin vaccination against respiratory syncytial virus (RSV), we investigated the immunogenicity, efficacy, and i...

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Bibliographic Details
Main Authors: Soojin Park, Youri Lee, Young-Man Kwon, Young-Tae Lee, Ki-Hye Kim, Eun-Ju Ko, Jae Hwan Jung, Manki Song, Barney Graham, Mark R Prausnitz, Sang-Moo Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6203256?pdf=render

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http://europepmc.org/articles/PMC6203256?pdf=render

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