Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter

Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter

Cell differentiation programs require dynamic regulation of gene expression. During meiotic prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit Ndc80 is downregulated by a 5’ extended long undecoded NDC80 transcript isoform. Here we demonstrate a transcriptional inter...

Full description

Bibliographic Details
Main Authors: Minghao Chia, Amy Tresenrider, Jingxun Chen, Gianpiero Spedale, Victoria Jorgensen, Elçin Ünal, Folkert Jacobus van Werven
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
transcription
chromatin
meiosis
interference
mRNA isoform
promoter
Online Access:https://elifesciences.org/articles/27420

Internet

https://elifesciences.org/articles/27420

Similar Items