Regulation of Bile Acid and Cholesterol Metabolism by PPARs
Bile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid synthesis is a major pathway for hepatic cholesterol catabolism. Bile acid synthesis generates bile flow which is important for biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics. Bi...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2009-01-01
|
Series: | PPAR Research |
Online Access: | http://dx.doi.org/10.1155/2009/501739 |
id |
doaj-91d292c99afa4c43945c589a6d53bba3 |
---|---|
record_format |
Article |
spelling |
doaj-91d292c99afa4c43945c589a6d53bba32020-11-25T00:59:57ZengHindawi LimitedPPAR Research1687-47571687-47652009-01-01200910.1155/2009/501739501739Regulation of Bile Acid and Cholesterol Metabolism by PPARsTiangang Li0John Y. L. Chiang1Department of Integrative Medical Sciences, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USADepartment of Integrative Medical Sciences, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USABile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid synthesis is a major pathway for hepatic cholesterol catabolism. Bile acid synthesis generates bile flow which is important for biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics. Bile acids are biological detergents that facilitate intestinal absorption of lipids and fat-soluble vitamins. Recent studies suggest that bile acids are important metabolic regulators of lipid, glucose, and energy homeostasis. Agonists of peroxisome proliferator-activated receptors (PPARα, PPARγ, PPARδ) regulate lipoprotein metabolism, fatty acid oxidation, glucose homeostasis and inflammation, and therefore are used as anti-diabetic drugs for treatment of dyslipidemia and insulin insistence. Recent studies have shown that activation of PPARα alters bile acid synthesis, conjugation, and transport, and also cholesterol synthesis, absorption and reverse cholesterol transport. This review will focus on the roles of PPARs in the regulation of pathways in bile acid and cholesterol homeostasis, and the therapeutic implications of using PPAR agonists for the treatment of metabolic syndrome.http://dx.doi.org/10.1155/2009/501739 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tiangang Li John Y. L. Chiang |
spellingShingle |
Tiangang Li John Y. L. Chiang Regulation of Bile Acid and Cholesterol Metabolism by PPARs PPAR Research |
author_facet |
Tiangang Li John Y. L. Chiang |
author_sort |
Tiangang Li |
title |
Regulation of Bile Acid and Cholesterol Metabolism by PPARs |
title_short |
Regulation of Bile Acid and Cholesterol Metabolism by PPARs |
title_full |
Regulation of Bile Acid and Cholesterol Metabolism by PPARs |
title_fullStr |
Regulation of Bile Acid and Cholesterol Metabolism by PPARs |
title_full_unstemmed |
Regulation of Bile Acid and Cholesterol Metabolism by PPARs |
title_sort |
regulation of bile acid and cholesterol metabolism by ppars |
publisher |
Hindawi Limited |
series |
PPAR Research |
issn |
1687-4757 1687-4765 |
publishDate |
2009-01-01 |
description |
Bile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid synthesis is a major pathway for hepatic cholesterol catabolism. Bile acid synthesis generates bile flow which is important for biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics. Bile acids are biological detergents that facilitate intestinal absorption of lipids and fat-soluble vitamins. Recent studies suggest that bile acids are important metabolic regulators of lipid, glucose, and energy homeostasis. Agonists of peroxisome proliferator-activated receptors (PPARα, PPARγ, PPARδ) regulate lipoprotein metabolism, fatty acid oxidation, glucose homeostasis and inflammation, and therefore are
used as anti-diabetic drugs for treatment of dyslipidemia and insulin insistence. Recent studies have shown that activation of
PPARα alters bile acid synthesis, conjugation, and transport, and also cholesterol synthesis, absorption and reverse cholesterol transport. This review will focus on the roles of PPARs in the regulation of pathways in bile acid and cholesterol homeostasis, and the therapeutic implications of using PPAR agonists for the treatment of metabolic syndrome. |
url |
http://dx.doi.org/10.1155/2009/501739 |
work_keys_str_mv |
AT tiangangli regulationofbileacidandcholesterolmetabolismbyppars AT johnylchiang regulationofbileacidandcholesterolmetabolismbyppars |
_version_ |
1725215157206908928 |