Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors

Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors

BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-stage disease. Early identification of DAWT h...

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Bibliographic Details
Main Authors: Taryn D. Treger, Tasnim Chagtai, Robert Butcher, George D. Cresswell, Reem Al-Saadi, Jesper Brok, Richard D. Williams, Chrissy Roberts, Nicholas M. Luscombe, Kathy Pritchard Jones, William Mifsud
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318301360

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http://www.sciencedirect.com/science/article/pii/S1936523318301360

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