Whole transcriptome analysis of the effects of type I diabetes on mouse oocytes.

Whole transcriptome analysis of the effects of type I diabetes on mouse oocytes.

In mouse ovarian follicles, granulosa cells but not oocytes take up glucose to provide the oocyte with nourishments for energy metabolism. Diabetes-induced hyperglycemia or glucose absorption inefficiency consistently causes granulosa cell apoptosis and further exerts a series of negative impacts on...

Full description

Bibliographic Details
Main Authors: Jun-Yu Ma, Mo Li, Zhao-Jia Ge, Yibo Luo, Xiang-Hong Ou, Shuhui Song, Dongmei Tian, Jin Yang, Bing Zhang, Ying-Chun Ou-Yang, Yi Hou, Zhonghua Liu, Heide Schatten, Qing-Yuan Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3404043?pdf=render

Internet

http://europepmc.org/articles/PMC3404043?pdf=render

Similar Items