The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases.

The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases.

Intralipid® administration at reperfusion elicits protection against myocardial ischemia-reperfusion injury. However, the underlying mechanisms are not fully understood.Sprague-Dawley rat hearts were exposed to 15 min of ischemia and 30 min of reperfusion in the absence or presence of Intralipid® 1%...

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Bibliographic Details
Main Authors: Phing-How Lou, Eliana Lucchinetti, Liyan Zhang, Andreas Affolter, Marcus C Schaub, Manoj Gandhi, Martin Hersberger, Blair E Warren, Hélène Lemieux, Hany F Sobhi, Alexander S Clanachan, Michael Zaugg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3907505?pdf=render

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http://europepmc.org/articles/PMC3907505?pdf=render

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