Microdialysis-directed Intra-tumor Pharmacokinetic Modeling of Methotrexate in Mice and Humans
Purpose. To develop a quantitative pharmacokinetic model to characterize the disposition of methotrexate (MTX) at tumor site in tumor-bearing mice and to predict MTX concentrations in the human tumor. Methods. The plasma profiles of MTX were obtained from normal mice, while microdialysis technique...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Canadian Society for Pharmaceutical Sciences
2016-07-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/26074 |