Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway

Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway

miRNA-21 is a single-stranded non-coding RNA that is highly expressed in a variety of tumor cells. It participates in tumor cell proliferation, metabolism, metastasis, and drug resistance. Here, we tested the potential mechanism of miRNA-21 in cisplatin-resistant non-small cell lung cancer A549/DDP...

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Bibliographic Details
Main Authors: Ye Sun, Wenjun Liu, Qiuyu Zhao, Ruiqi Zhang, Jianbo Wang, Pengyu Pan, Hai Shang, Chunying Liu, Chun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
cisplatin resistance
miRNA-21
PI3K/AKT/mTOR
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.653596/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.653596/full

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