Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

Abstract Background Ovarian carcinomas presenting homologous recombination deficiency (HRD), which is observed in about 50% of cases, are more sensitive to platinum and PARP inhibitor therapies. Although platinum resistant disease has a low chance to be responsive to platinum-based chemotherapy, a s...

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Bibliographic Details
Main Authors: Alexandre A. B. A. da Costa, Luisa M. do Canto, Simon Jonas Larsen, Adriana Regina Gonçalves Ribeiro, Carlos Eduardo Stecca, Annabeth Høgh Petersen, Mads M. Aagaard, Louise de Brot, Jan Baumbach, Glauco Baiocchi, Maria Isabel Achatz, Silvia Regina Rogatto
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Ovarian cancer
Homologous recombination deficiency
Target-next generation sequencing
Copy number alterations
Treatment response
CCNE1 gains
Online Access:http://link.springer.com/article/10.1186/s12885-019-5622-4

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http://link.springer.com/article/10.1186/s12885-019-5622-4

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