Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition

Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition

Abstract Background Our previous studies revealed that Jagged 2 (JAG2) is involved in the regulation of migration and invasion of colon cancer cells without affecting cell proliferation. This study further explored the specific mechanism by which JAG2 promotes migration and invasion of colorectal ca...

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Bibliographic Details
Main Authors: Wan He, Jun Tang, Wenwen Li, Yong Li, Yi Mei, Lisheng He, Keli Zhong, Ruilian Xu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cancer Cell International
Subjects:
Jagged 2 (JAG2)
Colorectal cancer
Epithelial–mesenchymal transition (EMT)
Notch
PRAF2
Online Access:http://link.springer.com/article/10.1186/s12935-019-0871-5

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http://link.springer.com/article/10.1186/s12935-019-0871-5

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