CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells

CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells

Mammalian telomere lengths are primarily regulated by telomerase, a ribonucleoprotein consisting of a reverse transcriptase (TERT) and an RNA subunit (TERC). TERC is constitutively expressed in all cells, whereas TERT expression is temporally and spatially regulated, such that in most adult somatic...

Full description

Bibliographic Details
Main Authors: Luan Wen, Changzhi Zhao, Jun Song, Linyuan Ma, Jinxue Ruan, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Peter X. Ma, Jie Xu
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
crispr/cas9
gene editing
telomerase
tert
cancer therapy
Online Access:https://www.mdpi.com/1422-0067/21/2/653

Internet

https://www.mdpi.com/1422-0067/21/2/653

Similar Items