Oral Immunization With a Plant HSP90-SAG1 Fusion Protein Produced in Tobacco Elicits Strong Immune Responses and Reduces Cyst Number and Clinical Signs of Toxoplasmosis in Mice

Oral Immunization With a Plant HSP90-SAG1 Fusion Protein Produced in Tobacco Elicits Strong Immune Responses and Reduces Cyst Number and Clinical Signs of Toxoplasmosis in Mice

Plant 90kDa heat shock protein (HSP90) is a potent adjuvant that increases both humoral and cellular immune responses to diverse proteins and peptides. In this study, we explored whether Arabidopsis thaliana HSP90 (AtHsp81.2) can improve the immune effects of a Toxoplasma gondii surface antigen 1 (S...

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Bibliographic Details
Main Authors: Edwin F. Sánchez-López, Mariana G. Corigliano, Sonia Oliferuk, Victor A. Ramos-Duarte, Maximiliano Rivera, Luisa F. Mendoza-Morales, Sergio O. Angel, Valeria A. Sander, Marina Clemente
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Plant Science
Subjects:
heat shock protein
SAG1
fusion protein
adjuvant
vaccine
toxoplasmosis
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2021.726910/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2021.726910/full

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