NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection

NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection

Although the crucial role of professional phagocytes for the clearance of S. aureus infections is well-established, several studies indicate an adverse role of leukocytes in the dissemination of S. aureus during infection. Since only little is known about macrophages in this context, we analyzed the...

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Bibliographic Details
Main Authors: Bettina Tosetti, Beate Ward, Daniela Grumme, Marc Herb, Michael Schramm, Olaf Utermöhlen, Lukas C. Heukamp, Martin Krönke, Oleg Krut
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
chronic granulomatous disease
Staphylococcus aureus
reactive oxygen species
antibiotic treatment
sepsis model
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.633629/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.633629/full

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