SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration. There exists a significant need to identify novel therapeutic targets and strateg...

Full description

Bibliographic Details
Main Authors: Ernest S. Smith, Alan Jonason, Christine Reilly, Janaki Veeraraghavan, Terrence Fisher, Michael Doherty, Ekaterina Klimatcheva, Crystal Mallow, Chad Cornelius, John E. Leonard, Nicola Marchi, Damir Janigro, Azeb Tadesse Argaw, Trinh Pham, Jennifer Seils, Holm Bussler, Sebold Torno, Renee Kirk, Alan Howell, Elizabeth E. Evans, Mark Paris, William J. Bowers, Gareth John, Maurice Zauderer
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
Remyelination
Neuroinflammation
Monoclonal antibody
Semaphorin-4D
Oligodendrocytes
Multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003015

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114003015

Similar Items