Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver[S]

Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver[S]

Osteopontin (OPN) is involved in different liver pathologies in which metabolic dysregulation is a hallmark. Here, we investigated whether OPN could alter liver, and more specifically hepatocyte, lipid metabolism and the mechanism involved. In mice, lack of OPN enhanced cholesterol 7α-hydroxylase (C...

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Bibliographic Details
Main Authors: Maitane Nuñez-Garcia, Beatriz Gomez-Santos, Xabier Buqué, Juan L. García-Rodriguez, Marta R. Romero, Jose J.G. Marin, Beatriz Arteta, Carmelo García-Monzón, Luis Castaño, Wing-kin Syn, Olatz Fresnedo, Patricia Aspichueta
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Journal of Lipid Research
Subjects:
glycerolipids
nonalcoholic fatty liver disease
de novo lipogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339602

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http://www.sciencedirect.com/science/article/pii/S0022227520339602

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