Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455.

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455.

Aberrant FGFR4 signaling has been documented abundantly in various human cancers. The majority of FGFR inhibitors display significantly reduced potency toward FGFR4 compared to FGFR1-3. However, LY2874455 has similar inhibition potency for FGFR1-4 with IC50 less than 6.4 nM. To date, there is no pub...

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Bibliographic Details
Main Authors: Daichao Wu, Ming Guo, Michael A Philips, Lingzhi Qu, Longying Jiang, Jun Li, Xiaojuan Chen, Zhuchu Chen, Lin Chen, Yongheng Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5019380?pdf=render

Internet

http://europepmc.org/articles/PMC5019380?pdf=render

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