FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.

FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.

Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension...

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Bibliographic Details
Main Authors: Yohannes T Ghebremariam, Keisuke Yamada, Jerry C Lee, Christine L C Johnson, Dorothee Atzler, Maike Anderssohn, Rani Agrawal, John P Higgins, Andrew J Patterson, Rainer H Böger, John P Cooke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3617194?pdf=render

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http://europepmc.org/articles/PMC3617194?pdf=render

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