The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Abstract We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti...

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Bibliographic Details
Main Authors: Beatrice Formicola, Roberta Dal Magro, Carlos V. Montefusco-Pereira, Claus-Michael Lehr, Marcus Koch, Laura Russo, Gianvito Grasso, Marco A. Deriu, Andrea Danani, Sandrine Bourdoulous, Francesca Re
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Nanobiotechnology
Subjects:
Nanoparticles
Liposomes
Brain
Blood–brain barrier
Drug delivery
Doxorubicin
Online Access:http://link.springer.com/article/10.1186/s12951-019-0546-3

Internet

http://link.springer.com/article/10.1186/s12951-019-0546-3

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