Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α1A/α1D-Adrenergic Receptor Antagonist with Potential Uroselective Profile

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α1A/α1D-Adrenergic Receptor Antagonist with Potential Uroselective Profile

Benign prostatic hyperplasia (BPH) is the most common male clinical problem impacting the quality of life of older men. Clinical studies have indicated that the inhibition of α1A-/α1D adrenoceptors might offer effective therapy in lower urinary tract symptoms. Herein, a limited s...

Full description

Bibliographic Details
Main Authors: Vittorio Canale, Aleksandra Rak, Magdalena Kotańska, Joanna Knutelska, Agata Siwek, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Paulina Koczurkiewicz, Elżbieta Pękala, Jacek Sapa, Paweł Zajdel
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
arylsulfonamides of alicyclic amines
α1-adrenoceptor antagonists
α1A/B/D receptor selectivity
silodosin
tamsulosin
uroselective activity
benign prostatic hyperplasia
Online Access:http://www.mdpi.com/1420-3049/23/9/2175

Internet

http://www.mdpi.com/1420-3049/23/9/2175

Similar Items