Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-β peptide levels in vivo

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-β peptide levels in vivo

ABCA1-deficient mice have low levels of poorly lipidated apolipoprotein E (apoE) and exhibit increased amyloid load. To test whether excess ABCA1 protects from amyloid deposition, we crossed APP/PS1 mice to ABCA1 bacterial artificial chromosome (BAC) transgenic mice. Compared with wild-type animals,...

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Bibliographic Details
Main Authors: Veronica Hirsch-Reinshagen, Jennifer Y. Chan, Anna Wilkinson, Tracie Tanaka, Jianjia Fan, George Ou, Luis F. Maia, Roshni R. Singaraja, Michael R. Hayden, Cheryl L. Wellington
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
apolipoprotein E
Alzheimer's disease
animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434443

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http://www.sciencedirect.com/science/article/pii/S0022227520434443

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