Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

<p>Abstract</p> <p>Background</p> <p>The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear. We report...

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Bibliographic Details
Main Authors: Wang Qingshan, Shin Eun-Joo, Nguyen Xuan-Khanh, Li Quan, Bach Jae-Hyung, Bing Guoying, Kim Won-Ki, Kim Hyoung-Chun, Hong Jau-Shyong
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
methamphetamine
neuroinflammation
microglia
dynorphin
prodynorphin-deficient mice
nigrostriatal dopaminergic toxicity
behavioral deficit.
Online Access:http://www.jneuroinflammation.com/content/9/1/124

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http://www.jneuroinflammation.com/content/9/1/124

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