Novel PITX2 Homeodomain-Contained Mutations from ATRIAL Fibrillation Patients Deteriorate Calcium Homeostasis

Novel PITX2 Homeodomain-Contained Mutations from ATRIAL Fibrillation Patients Deteriorate Calcium Homeostasis

Atrial fibrillation (AF) is the most common cardiac arrhythmia in the human population, with an estimated incidence of 1–2% in young adults but increasing to more than 10% in 80+ years patients. Pituitary Homeobox 2, Paired Like Homeodomain 2 (PITX2c) loss-of-function in mice revealed that this home...

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Bibliographic Details
Main Authors: Adela Herraiz-Martínez, Carmen Tarifa, Estefanía Lozano-Velasco, Verónica Jiménez-Sábado, Sergi Casabella, Francisco Hernández-Torres, Houria Daimi, Eduardo Vázquez Ruiz de Castroviejo, Eva Delpón, Ricardo Caballero, Amelia Aránega, Diego Franco, Leif Hove-Madsen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Hearts
Subjects:
atrial fibrillation
PITX2 mutations
sarcoplasmic reticulum
calcium imaging
cardiomyocyte culture
Online Access:https://www.mdpi.com/2673-3846/2/2/20

Internet

https://www.mdpi.com/2673-3846/2/2/20

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