Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia1

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia1

The objective of our study was to determine the mechanism of action of the short-chain ceramide analog, C6-ceramide, and the breast cancer drug, tamoxifen, which we show coactively depress viability and induce apoptosis in human acute myelogenous leukemia cells. Exposure to the C6-ceramide-tamoxifen...

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Bibliographic Details
Main Authors: Samy A.F. Morad, Terence E. Ryan, P. Darrell Neufer, Tonya N. Zeczycki, Traci S. Davis, Matthew R. MacDougall, Todd E. Fox, Su-Fern Tan, David J. Feith, Thomas P. Loughran, Jr., Mark Kester, David F. Claxton, Brian M. Barth, Tye G. Deering, Myles C. Cabot
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Lipid Research
Subjects:
ceramides
sphingolipids
leukemia
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351592

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http://www.sciencedirect.com/science/article/pii/S0022227520351592

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