Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice.

Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice.

Cystic fibrosis (CF) patients often have reduced mass and strength of skeletal muscles, including the diaphragm, the primary muscle of respiration. Here we show that lack of the CF transmembrane conductance regulator (CFTR) plays an intrinsic role in skeletal muscle atrophy and dysfunction. In norma...

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Bibliographic Details
Main Authors: Maziar Divangahi, Haouaria Balghi, Gawiyou Danialou, Alain S Comtois, Alexandre Demoule, Sheila Ernest, Christina Haston, Renaud Robert, John W Hanrahan, Danuta Radzioch, Basil J Petrof
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2709446?pdf=render

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http://europepmc.org/articles/PMC2709446?pdf=render

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