Critical role of iron in the pathogenesis of the murine gangliosidoses

Critical role of iron in the pathogenesis of the murine gangliosidoses

Neurodegeneration is a prominent feature of the gangliosidoses, a group of lysosomal storage diseases. Here we show altered iron homeostasis in mouse models of both GM1 and GM2 gangliosidoses, which are characterized by progressive depletion of iron in brain tissue. This finding contrasts with the f...

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Bibliographic Details
Main Authors: Mylvaganam Jeyakumar, Ian Williams, David A. Smith, Timothy M. Cox, Frances M. Platt
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neurobiology of Disease
Subjects:
Lysosomal storage disease
Gangliosidosis
Iron
Glycosphingolipid
Mouse disease models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000114

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http://www.sciencedirect.com/science/article/pii/S0969996109000114

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