Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure

Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure

Background: Our previous GWAS identified genetic variants at six novel loci that were associated with a decline in left ventricular ejection fraction (LVEF), p < 1 × 10−5 in 1,191 early breast cancer patients from the N9831 clinical trial of chemotherapy plus trastuzumab. In this study we sou...

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Bibliographic Details
Main Authors: Nadine Norton, Julia E. Crook, Liwei Wang, Janet E. Olson, Jennifer M. Kachergus, Daniel J. Serie, Brian M. Necela, Paul G. Borgman, Pooja P. Advani, Jordan C. Ray, Carolyn Landolfo, Damian N. Di Florio, Anneliese R. Hill, Katelyn A. Bruno, DeLisa Fairweather
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
anthracycline
doxorubicin
trastuzumab
breast cancer
cardiomyopathy
cardiotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00142/full

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https://www.frontiersin.org/article/10.3389/fcvm.2020.00142/full

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