Adeno-Associated Virus Mediated Gene Delivery: Implications for Scalable in vitro and in vivo Cardiac Optogenetic Models

Adeno-Associated Virus Mediated Gene Delivery: Implications for Scalable in vitro and in vivo Cardiac Optogenetic Models

Adeno-associated viruses (AAVs) provide advantages in long-term, cardiac-specific gene expression. However, AAV serotype specificity data is lacking in experimental models relevant to cardiac electrophysiology and cardiac optogenetics. We aimed to identify the optimal AAV serotype (1, 6, or 9) in pu...

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Bibliographic Details
Main Authors: Christina M. Ambrosi, Gouri Sadananda, Julie L. Han, Emilia Entcheva
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
AAV
cardiac optogenetics
channelrhodopsin-2
LamR
sialic acid
iPS-CM
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00168/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00168/full

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